Improvement of renal hypoplasia and cystic dysplasia with re-expression of bcl-2 in the ureteric bud/collecting duct of bcl-2 -/- mice

Abstract

 Bcl-2 is the founding member of a family of proteins that influence apoptosis. Loss of bcl-2 results in renal hypoplasia/cystic dysplasia at birth. In this review, we show that re-expression of bcl-2 in the ureteric bud/collecting duct resulted in increased nephron numbers partially rescuing renal hypoplasia/cystic dysplasia in bcl-2 -/- mice.