Abstract
We studied long-term clinicopathologic analysis of 258 pediatric patients with idiopathic nephrotic syndrome started in childhood, especially of 50 patients who carried over (CO) the disease to adulthood. This study has been done from 1980 to 2010 by our institute and National Hospital Organization Okayama Medical Center. The propotion of the carry over the disease to adulthood was approximately 20% of the patients. The characteristics of CO were 1) the onset of the disease was slightly younger than non-CO and 2) the type of relapse was mainly frequent type. Furthermore, the more younger the onset, more likely with the clonicity. The patients with idiopathic nephrotic syndrome tended to show complete remission until their puberty period. And even the carry over occurred, renal function did not become worse and response to steroid-sensitivity to relapse was still fine and stable. Another problem regarding CO is certainly impairment of social adjustment for the patients.
