The mechanisms of progressive glomerulosclerosis

Exploring from the aspect of glomerular hemodynamics

Abstract

In this review, I introduce the strategy developed by our laboratory to explore the mechanisms of progressive glomerulosclerosis leading to renal death, including the animal model of irreversible glomerulosclerosis, imaging analysis of glomerular hemodynamics and therapeutic approach. In particular, I stress that our imaging system allows us to evaluate the progression of disease and the therapeutic effects of renoprotection as a diagnostic tool in the chronic kidney disease resulting in cardiovascular events.