C3 glomerulonephropathy in a 13-year-old boy with Down syndrome

Abstract

We report on a 13-year-old boy with Down syndrome and recurrent bacterial infections such as otitis media who developed hematuria,proteinuria, and persistent hypocomplementemia due to C3 glomerulopathy. The histology on first renal biopsy showed MPGN type 2. The patient was intravenously treated with methylpredonisolone pulses followed by cyclosporine and showed remarkable improvement in the urinary abnormalities. Two years after initial treatment, a second renal biopsy was performed and the histology revealed C3 glomerulopathy. We conclude that urinalysis should be regularly performed in children with Down syndrome who had repeated episodes of bacterial infections.