Abstract
Here, we report two patients diagnosed with tubulo-interstitial nephritis and uveitis (TINU) syndrome. One patient was a 14-year-old girl, admitted to our hospital because of prolonged fever and fatigue. Her urine examination revealed high level of urinary β2 microglobulin, and ophthalmological findings revealed features of uveitis. The other patient, a 13-year-old girl, complained of redness of right eye only, and was diagnosed with uveitis by an ophthalmologist. She was referred to our hospital under the suspicion that she was suffering from systemic inflammatory response syndrome. Renal biopsies were performed in both patients, showing the findings of tubulo-interstitial nephritis, and they were diagnosed with TINU syndrome. Oral prednisolone was prescribed to treat uveitis in both of the cases; however, following dose reduction of prednisolone, uveitis relapsed in both of them. Subsequent addition of mizoribine with oral prednisolone led to satisfactory management of uveitis without relapse in both cases. Hence, we suggest that uveitis associated with TINU syndrome, which is recurrent in nature and runs a chronic course, can be effectively managed by mizoribine along with prednisolone.
