Renal outcome after hemopoietic stem cell transplantation

Abstract

Renal impairment is one of the serious complication caused by hematopoietic stem cell transplantation (HSCT). Acute kidney injury (AKI) and chronic kidney disease (CKD) both could greatly affect prognosis and quality of life. In this study, we retrospectively analyzed the data of 72 pediatric patients with hematologic disease who underwent allogeneic HSCT to identify the incidence and risk factors of AKI and CKD after HSCT. The incidence of AKI was 59.7%, of which 4.7% required renal replacement therapy. The risk factor of AKI after HSCT was myeloablative conditioning (MAC). The cumulative incidence of CKD was 18.2%, of which 10% had stage 3. The risk factor of CKD was AKI after HSCT. In conclusion, AKI and CKD after HSCT were not uncommon. Early intervention of pediatric nephrologists, in cooperation with pediatric hematologists, would be recommended to prevent the onset and control the progression of AKI in patients with HSCT.