2024 Volume 37 Pages 103-109
Background and Purpose: Tubulointerstitial nephritis (TIN) can present with a variety of symptoms. The relationship between initial symptoms and renal prognosis is still unknown. Methods: We performed a retrospective analysis of the clinical course and renal outcome of 14 patients diagnosed with TIN in our hospital. Initial symptoms were classified into three groups: proteinuria detected by school urinalysis screening in 4 patients, ocular symptoms in 7 patients, and fever in 3 patients. Results: The median follow-up period was 27.4 months (range: 5.6–86.6 months). At the time of diagnosis, the median estimated glomerular filtration rate (eGFR) was 76.2, 103.1, and 83.1 mL/min/1.73 m2, in school urinalysis screening, ocular symptoms, and fever groups, respectively. The school urinalysis screening and fever groups had lower eGFRs than the ocular symptoms group. At the last observation, the median eGFR was 86.7, 107.8, and 90.9 mL/min/1.73 m2, respectively, with the school urinalysis screening group having a lower eGFR than the ocular symptoms group. Conclusion: Patients in school urinalysis screening group may have longer duration from symptom onset to diagnosis and treatment. The duration from symptom onset to treatment may affect the renal prognosis.
