Japanese journal of pediatric nephrology
Online ISSN : 1881-3933
Print ISSN : 0915-2245
ISSN-L : 0915-2245
Original Article
Clinicopathologic study of childhood-onset membranoproliferative glomerulonephritis
Ryutaro Hisatomi Rika FujimaruTakahiro Fujii
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JOURNAL OPEN ACCESS

2025 Volume 38 Article ID: oa.24-025

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Abstract

Background: Membranoproliferative glomerulonephritis (MPGN) is classified into immune complex-associated MPGN (IC- MPGN), C3 glomerulonephritis (C3GN), and dense deposit disease (DDD). These diseases are rare and not fully understood. Objectives and Methods: To clarify the clinicopathological characteristics of MPGN, we retrospectively studied childhood-onset MPGN cases pathologically diagnosed and followed for more than 2 years in our division. Results: A total of 9 patients were included: 3 with IC- MPGN, 5 with C3GN, and 1 with DDD. The most common detection method was school urinalysis. At the time of diagnosis, two patients had nephrotic syndrome, and one patient had renal dysfunction in the IC-MPGN group. However, no patients in the C3GN or DDD groups presented with these symptoms. At the last follow-up, none of the patients had nephrotic syndrome or renal dysfunction, but 8 patients still required medication. Conclusions: Most childhood-onset MPGN cases were identified through school urinalysis. Despite persistent hypocomplementemia in serum C3 levels, short-term renal function was preserved.

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© 2025 The Japanese Society for Pediatric Nephrology

この記事はクリエイティブ・コモンズ [表示 - 非営利 - 継承 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja
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