2025 Volume 38 Article ID: oa.24-025
Background: Membranoproliferative glomerulonephritis (MPGN) is classified into immune complex-associated MPGN (IC- MPGN), C3 glomerulonephritis (C3GN), and dense deposit disease (DDD). These diseases are rare and not fully understood. Objectives and Methods: To clarify the clinicopathological characteristics of MPGN, we retrospectively studied childhood-onset MPGN cases pathologically diagnosed and followed for more than 2 years in our division. Results: A total of 9 patients were included: 3 with IC- MPGN, 5 with C3GN, and 1 with DDD. The most common detection method was school urinalysis. At the time of diagnosis, two patients had nephrotic syndrome, and one patient had renal dysfunction in the IC-MPGN group. However, no patients in the C3GN or DDD groups presented with these symptoms. At the last follow-up, none of the patients had nephrotic syndrome or renal dysfunction, but 8 patients still required medication. Conclusions: Most childhood-onset MPGN cases were identified through school urinalysis. Despite persistent hypocomplementemia in serum C3 levels, short-term renal function was preserved.
