Article ID: rv.2020.0003
The intrarenal renin-angiotensin system has a crucial role in the pathophysiologic functions in not only hypertension but also chronic kidney disease. Previous studies have reported that enhanced intrarenal angiotensinogen levels have been demonstrated in various renal injuries, suggesting that angiotensinogen involves in the mechanism of kidney disease. Furthermore, recent reports showed that urinary excretion rates of angiotensinogen reflect a specific index of the intrarenal renin-angiotensin system status and kidney development in neonates. Also, angiotensin converting enzyme (ACE) 2, a homolog of ACE, associates with mesangial hypercellularity of pediatric IgA nephropathy. In addition, (pro) renin receptor has a key role in physiological function and the pathogenesis of crescent formation in rat glomerulonephritis model. The pleiotropic roles of activated intrarenal renin-angiotensin system in the progression of kidney disease are being investigated in ongoing studies.
