Consideration of Bone Regeneration Induced by Laser Irradiation on the Basis of Wolff's Law and Frost's Mechanostat Thresholds

Abstract

Recently, osteocytes embedded in mineralized matrix have attracted much research attention as they are thought to translate mechanical loading into biochemical signals that affect bone (re) modeling. In order to understand the biological mechanisms by which osteocytes control bone formation and resorption under mechanical force, we conducted a study in the light of Wolff's Law and Frost's mechanical thresholds theory. The findings indicate that mechanical stress can be used for bone regeneration therapy. We have demonstrated that carbon dioxide laser irradiation induces bone formation, and that laser irradiation is a kind of mechanical force and so could be used for bone regeneration therapy. Here, we review how laser irradiation influences bone metabolism via osteocytes on the basis of Wolff's Law and Frost's mechanostat thresholds theory.