Abstract
We analyzed 1087 samples of sputum in less than 7 year-old children diagnosed as pneumonia or bronchitis for four years during 2000-2003.As compared with Streptococcus pneumoniae or Moraxella catarrhalis strains, the degree of tolerance to antibiotics was advancing in Haemophilus influenzae strains.And it was especially for cephalosporins.In inpatients diagnosed as pneumonia or bronchitis caused by Haemophilus influenzae, there was no significant tendency in the rate of invalid cases to initial treatment.However, the rate for which β-lactamase negative ampicillin resistant Haemophilus influenzae (BLNAR) strains accounts among invalid cases was increasing explosively from 10% in 2000 to 70% in 2003.From now on, it is expected that invalid or troubled cases increase for BLNAR strains.Insufficient serum concentration of oral cephalosporins prescribed for immunological immature pediatric patients accelerate the increase of BLNAR strains.In pediatric practice, proper use of antibiotics is required.
