口唇の違和感がParkinson病初発症状であった一例

宇津宮 雅史; 松岡 紘史; 吉田 光希; 神野 由貴; 森谷 満; 安彦 善裕

doi:10.11268/jjpsd.39.1-2_34

Case Reports

A case of lip discomfort as the initial symptom of Parkinson’s

Masafumi Utsunomiya, Hirofumi Matsuoka, Koki Yoshida, Yoshitaka Kamino, Mitsuru Moriya, Yoshihiro Abiko

Author information

Masafumi Utsunomiya
Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Oral Medicine Consultation Clinic, Health Sciences University of Hokkaido Hospital
Hirofumi Matsuoka
Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
Koki Yoshida
Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Oral Medicine Consultation Clinic, Health Sciences University of Hokkaido Hospital
Yoshitaka Kamino
Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Sapporo Mund und Kiefergesichtschirurgie
Mitsuru Moriya
Division of Medical Psychology, Health Sciences University of Hokkaido Hospital
Yoshihiro Abiko
Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
Oral Medicine Consultation Clinic, Health Sciences University of Hokkaido Hospital

Keywords: oral dysesthesia, Parkinson’s disease, drug-induced Parkinsonism

RESEARCH REPORT / TECHNICAL REPORT RESTRICTED ACCESS

2025 Volume 39 Issue 1-2 Pages 34-37

DOI https://doi.org/10.11268/jjpsd.39.1-2_34

Details

Abstract

Parkinson’s disease （PD） often presents non-motor symptoms, such as mood disorders and sensory abnormalities, during its prodromal phase. We report a case of a patient diagnosed with PD during treatment for oral dysesthesia.
A 64-year-old male with a history of depression presented with persistent lip discomfort. Despite supportive psychotherapy and medication adjustments, his symptoms progressed over several years, including systemic fatigue, oral dysesthesia, and lip tremors. These led to a diagnosis of PD.
Abnormal oral sensations may be prodromal non-motor symptoms of PD, warranting careful evaluation in similar cases.

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