Abstract
The effect of intravenous sedation on dopamine metabolism in rat striatum was examined by electric stimulation or formalin injection after administration of 0.15mg/kg midazolam using the method of microdialysis. In the group given electric stimulation after administration of physiological saline, the dopamine levels increased significantly after stimulation. In the group given both midazolam and electrical stimulation, the dopamine level did not change significantly. In the group given formalin after administration of physiological saline and the group given both midazolam and formalin the dopamine levels did not change following injection.
