Abstract
We administered milnacipran hydrochloride, one of the 4th-generation antidepressants, to patients with oral diseases in which the intervention of psychosocial factors was strongly suspected. The eight subjects consisted of five cases of glossalgia, one of dysgeusia, and two of oral discomfort. The dose levels were 15mg in six and 30mg in two cases. Five patients olso received other medicaments jointly due to the insufficient efficacy of previous chemotherapy. The jointly used agents included anxiolytics, autonomic regulators, cevimeline. hydrochloride, and Hangekobokuto. The remaining three were given milnacipran hydrochloride alone.
The effects were evaluated by means of SRS after four weeks. The symptoms were alleviated in six cases but unchanged in two. Of the subjects taking milnacipran hydrochloride alone, two improved but one did not.
>From the foregoing, we concluded that the administration of milnacipran.hydrochloride.is effective for use with such oral diseases as glossalgia.
