2022 Volume 25 Issue 1 Pages 80-85
Patients with chronic kidney disease (CKD) have decreased physical activity and exercise tolerance because of various complications and disuse. Reduced physical activity and exercise tolerance are associated with increased mortality risk. Recently, exercise training for CKD has been reported to not only improve physical function and prognosis but also renal function. CKD rat models in some basic studies have demonstrated a renoprotective effect on exercise training. However, the detailed mechanism is unclear. We focused on renal interstitial fibrosis, which is observed in advanced CKD stages. We have reported the involvement of the renal collagen metabolism and renal renin-angiotensin system in the inhibitory effect mechanism of exercise training on renal interstitial fibrosis. Based on the results, exercise training for CKD is expected to prevent renal interstitial fibrosis and have a preventive effect on renal failure progression.
