Cellular Senescence and Skeletal Muscle Regeneration

Abstract

Cellular senescence, a state of irreversible cell cycle arrest, contributes to normal embryonic development and remodeling after tissue damage. On the other hand, the accumulation of senescent cells is a hallmark of aging tissues or pathological contexts and may lead to progressive tissue degeneration. The mechanisms responsible for the effects of senescent cells have not been fully elucidated. Here, we review current knowledge about the beneficial and detrimental effects of senescent cells in skeletal muscle regeneration, degeneration, and aging.