2024 Volume 2 Pages 22-31
Objects: The single-center retrospective cohort study aimed to detect the optimal cutoff point of skeletal muscle mass loss after esophagectomy in Japanese patients with esophageal cancer.
Methods: Subjects were patients with esophageal cancer who had undergone curative esophagectomy at National Cancer Center Hospital East in Japan between 2016 and 2020. Skeletal muscle mass index (SMI) loss was calculated with computer tomography images at preoperatively and four months after surgery. The optimal cutoff point of SMI loss was detected using the Log-rank test.
Results: A total of 384 patients were analyzed. The average SMI loss was 4.6%. The optimal cutoff point of SMI loss was detected as 10% (Chi-square value: 19.8, p < 0.001). A larger SMI loss than 10% had a significant impact on 3-year overall survival, resulting from the Cox proportional hazard model [Adjusted hazard ratio: 3.864 (95% confidence interval: 2.054–7.267), p < 0.001].
Conclusion: This present study showed that the optimal cutoff point of skeletal muscle mass loss after esophagectomy was 10% using survival as an anchor.
