2019 Volume 38 Issue 1 Pages 1-4
A woman in her 30s was hospitalized for suspected anti-NMDA receptor encephalitis. After intravenous administered of haloperidol for restless, her body temperature rapidly increased to the 39℃ level, she developed shock and entered the ICU in an emergency. Sixty mg of dantrolen as a diagnosis for malignant syndrome was intravenously administered. Central cooling with 1 L normal saline fast infusion and surface cooling with Arctic SunTM were performed. Her body temperature reached a maximum of 40.8 ℃, but decreased to 39.2 ℃ in 1 hour after cooling and 38.2 ℃ by 2 hours. Rapid cooling also stabilized hemodynamics. For acute renal injury, temporary continuous hemodiafiltration therapy was performed, but she had not any complications.
Early withdrawal from abnormal hyperthermia and normalization of body temperature was useful because hyperthermia alone can cause multiple organ failure and result in death.
