Cyclophilin D and brain protection

Abstract

Among the triggering mechanisms of ischemic brain damage, mitochondrial dysfunction has recently attracted attention in neuropathy. Mitochondrial dysfunction, especially a phenomenon called mitochondrial permeability transition (MPT), is an important early event in mitochondrial-mediated cell death, and activation of the CypD (cyclophilin D) protein present in the mitochondrial matrix that play an important role to induce primary phenomenon. MPT with the involvement of F1F0ATPsynthase has been focused. In this article, I would like to reconsider the roles of cyclophilin D and MPT, which have the multiple functions for the cell homeostasis.