Three cases of anti-PM-Scl antibody-positive interstitial lung disease with differing clinical courses and imaging findings

Abstract

Anti-PM-Scl antibody-positive interstitial lung disease (ILD) presents with diverse clinical manifestations. We report three cases with different clinical courses and imaging findings. The first case involved slowly progressive ILD with muscle symptoms, the second case was a rapidly progressive ILD without muscle symptoms, and the third case was a subacute ILD with both muscle and skin symptoms. Considering the heterogeneity of clinical presentations and imaging findings, testing for anti-PM-Scl antibodies is clinically significant in ILD patients with unclear diagnoses but features suggestive of collagen vascular disease.