Abstract
A case of primary macroglobulinemia with lung involvement was reported. The patient, a 30 year-old male, was admitted to our hospital because of cough and weight loss. His chest X-ray showed left pleural effusion and an abnormal shadow in the right lung field. Protein fraction studies of plasma and pleural fluid revealed a monoclonal M band which was identified as IgM-K type by immunoelectrophroresis. Cytologically, there were many abnormal lymphocytoid and plasmacytoid cells in the pleural fluid. These abnormal cells stained positively with fluorescein-conjugated antisera to K-chains, μ-chains and to both. Diagnosis of primary macroglobulinemia was made, although there was no lymphoadenopathy, anemia, hepatosplenomegaly and hyperviscosity syndrome. Abdominal lymphography showed no abnormalities.
From these findings, we concluded that the macroglobulinemia in this case originated from and was confined to the pleuropulmonary lesion.
