Immunological Studies on Allergic Bronchopulmonary Aspergillosis

Probably Induced by Aspergillus Oryzae

Abstract

Clinical and immunological studies were performed in one case with allergic bronchopulmonary aspergillosis probably induced by Aspergillus oryzae. The results are summarized as follows.
1) Skin tests showed positive immediate and late reactions to commercial aspergillus extract.
2) A positive PK reaction and positive bronchial provocation test were recognized to the aspergillus extract.
3) Precipitating antibodies to the aspergillus extract were positive.
4) Aspergillus oryzae was successively cultured from sputa of the patient. Skin reactions and precipitating antibodies to A. oryzae were positive. These results showed cross reaction between A. fumigatus and A. oryzae. It may suggest strongly that this allergic bronchopulmonary aspergillosis was induced by A. oryzae.
5) The chest X-ray demonstrated micronodular shadowing evenly distributed through both lung fields and upper lobe infiltrate with tubular shadows.
Type I allergic reaction mediated by IgE, partially mediated by IgG S-T S was suggested to participate in this case. The participation of type III allergic reaction was supposed by: (1) positive precipitating antibodies to Aspergillus, (2) positive late reaction to Aspergillus both in skin test and bronchial provocation test, (3) micronodular shadowing distributed through both lung fields on the chest X-ray, although further examinations are needed for type III or type IV allergic reaction.