Abstract
The acute effects of intravenously administered sodium hydrocortisone succinate was estimated primarily by respiratory resistance as an indicative parameter, and in addition comparison among different dosages and different administration techniques were examined in adult asthmatics with middle-grade acute attacks. Twenty three patients were randomly selected, and they were divided into three groups.
The first group received a rapid bolus injection of 100mg prior to receiving 300mg in 500ml fluid over 3hrs. The second group was given only a rapid bolus injection of 300mg. The third group received a rapid bolus injection of 300mg prior to receibing 900mg in 500ml fluid over 3hrs. Each group was observed for symptoms andphysical findings, which included the time course of respiratory resistance, plasma 11-OHCS levels and arterial blood gas analysis until 6hrs after administration of the drug.
A slight fall in respiratory resistance and temporary subjective improvement were observed as the acute effects of intravenously infusing sodium hydrocortisone succinate. Except for blood gas level definite beneficialeffects, however, appeared approximately 1hr after in almost every case.
