Abstract
Experimental and clinical studies on bronchopulmonary absorption of antibiotics with hydrocortisone and salbutamol hemisulfate were performed. Antibiotics (gentamicin, cefazolin and ampicillin) with hydrocortisone were injected into the patients' lower segmental bronchi through a bronchial catheter (16 Fr.) and serum concentrations of the antibiotics were measured by means of a bioassay. Serum levels of intrabronchial gentamicin and cefazolin with hydrocortisone were higher than those of gentamicin and cefazolin only. However serum levels of intrabronchial ampicillin with hydrocortisone were almost equal to those of ampicillin alone.
Antibiotics (gentamicin, cefazolin and ampicillin) with hydrocortisone and salbutamol hemisulfate were injected into rabbit trachea through a teflon tube (70mm in length, 18 gauge). Serum levels of intratracheal gentamicin and cefazolin with hydrocortisone and salbutamol hemisulfate were higher than those of gentamicin and cefazolin only. But serum levels of intratracheal ampicillin with hydrocortisone and salbutamol hemisulfate were almost equal to those of amplicillin alone.
Our findings were as follows. Intrabronchial gentamicin and cefazolin induced bronchospasm, so that bronchopulmonary absorption of these antibiotics was low without hydrocortisone and salbutamol hemisulfate. On the other hand, intratracheobronchial amplicillin did not induce bronchospasm, so that bronchopulmonary absorption of amplicilli was the same with or without hydrocortisone and salbutamol hemisulfate.
