A Case of Prednisolone Effective Lymphoid Interstitial Pneumonia with Monoclonal Hypergammaglobulinemia

Abstract

A 74-year old female suffering from cough, sputum and fever of 2 months duration was transfered to UOEH pulmonary division, because of failure to various antibiotic or antituberculous treatment. Transbronchial lung biopsy (TBLB) revealed infiltration of lymphocytes and thickening of alveolar interstitium with IgA deposition. Serum immunological examination showed monoclonal IgA κ type hypergammaglobulinemia. There was no evidence of multiple myeloma. Marked clinical and radiological improvement was attained after prednisolone administration. This case provides information concerning the pathogenesis of LIP.