Indications for Home Oxygen Therapy in Cases of Sleep Oxygen Desaturation

Abstract

Home oxygen therapy is now considered indicated in cases of severe sleep oxygen desaturation.
To explore whether we could choose cases with severe sleep desaturation by measurement of waking physiological parameters, we examined the relationship between arterial blood gases, lung functions and pulmonary artery pressure while awake and the degree of sleep oxygen desaturation in 21 patients with chronic obstructive pulmonary disease and 22 cases with a past history of pulmonary tuberculosis. There were significant correlations between waking Pa_O2, Pa_CO2 and pulmonary artery mean pressure and sleep lowest Sa_O2, respectively, whereas no significant relation was found between %VC or FEV_1.0% and sleep lowest Sa_O2. However, we found wide ranges of Pa_O2 and Pa_CO2 in cases who had 10min or more with Sa_O2 below 85% during sleep. This was also true in the patients who underwent 60min or more with Sa_O2 below 85% while a sleep. These results suggest that it may be difficult to find out the indications for cases with severe sleep desaturation by evaluation of arterial blood gases while awake.