The Japanese journal of thoracic diseases
Online ISSN : 1883-471X
Print ISSN : 0301-1542
ISSN-L : 0301-1542
Blood Gas Changes in Duchenne Type Muscular Dystrophy
Tomoaki TakasugiTadayuki IshiharaJunn KawamuraKazuya SasakiTakeo ToyodaMitsuhiko OosumiKouichi SuzukiKazumi NishioTeruo AoyagiTakeo Kawashiro
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1995 Volume 33 Issue 1 Pages 17-22

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Abstract
We studied changes in blood gas data from 32 patients with Duchenne type muscular dystrophy (DMD), who were followed for more than 5 years. Regression lines for each blood gas variable were obtained by the least square regression method, from 276 observations. The mean change per year was calculated by averaging the individual slolpes.
All blood gas variables (PaO2, PaCO2, pH, and [HCO3-]) correlated significantly with age the regression lines were:
PaO2=95.6-0.45×Age, PaCO2=34.7+0.70×Age, pH=7.397-0.0023× Age, [HCO3-]=20.7+0.28×Age.
The rates of change were-0.74 Torr/year for PaO2, 1.07 Torr/year for PaCO2, -0.0028 per year for pH and 0.55mEq/l/year for [HCO3-]. The slope of each regression line was within the average individual yearly change±one standard deviation. AaDo2 did not change significantly with age, but chronic respiratory acidosis worsened because of alveolar hypoventilation.
As an index of the severity of DMD, PaCO2 was better than PaO2, because the former was more strongly correlated with age and the values of PaCO2 deviated less from the regression line.
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© by The Japanese Respiratory Society
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