Specificity of Plasma Peroxidized Low Density Lipoprotein in Lung Cancer

Abstract

Plasma was sampled from patients with lung cancer (LC: n=38), patients with atherosclerotic disease (AS: n= 20), and healthy persons (H: n=32). Lipid peroxide and lipid constituents of low density lipoprotein (LDL) were measured after sequential ultracentrifugation.
Lipid peroxide levels in LDL were in the following order: LC>AS>H. Cholesteryl ester, triglycerides, free fatty acid, free cholesterol, and phospholipids were stained on plates of thin-layer chromatography of LDLs in healthy persons. However, spot X₁ between triglycerides and free fatty acid was clearly colored on those of patients with atherosclerotic disease, and clear spot X₂ between free fatty acid and free cholesterol, and a little spot X1 was stained on those of patients with lung cancer except for the lipid constituents mentioned above. No significant differences in lipid constitutents were found among the patients with different histological types of lung cancer.
Although lipid peroxide concentrations were significantly higher in the patients with lung cancer and artherosclerotic disease than in healthy persons, there were marked differences between patients with lung cancer and patients with artherosclerotic disease in the constituents of LDL lipid peroxide.