A Case of Multifocal Langerhans Cell Granulomatosis A BAL follow up Study

Hiromi Tomioka; Riyo Fujiyama; Hisashi Ohnishi; Toshiyasu Sakurai; Kimihide Tada; Hiroko Sakamoto; Hironobu Iwasaki; Kazufumi Imanaka; Kimio Hashimoto

doi:10.11389/jjrs1963.35.1389

A Case of Multifocal Langerhans Cell Granulomatosis

A BAL follow up Study

Hiromi Tomioka, Riyo Fujiyama, Hisashi Ohnishi, Toshiyasu Sakurai, Kimihide Tada, Hiroko Sakamoto, Hironobu Iwasaki, Kazufumi Imanaka, Kimio Hashimoto

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Keywords: Eosinophilic granuloma, Lymph node, Hand-Schueller-Christian disease, BAL, Langerhans cell granulomatosis

JOURNAL FREE ACCESS

1997 Volume 35 Issue 12 Pages 1389-1394

DOI https://doi.org/10.11389/jjrs1963.35.1389

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Abstract

Langerhans cell granulomatosis, once called histiocytosis X, is a rare disease. A case of multifocal Langerhans cell granulomatosis in the bone, lymph nodes, skin and lungs of an 18-year-old man is described. Head CT and MRI showed a soft tissue mass of the left temporal bone. Lymph node and skin biopsies substantiated a diagnosis of Langerhans cell granulomatosis. A High resolution CT scan of the lung revealed a small cystic lesion, and bronchoalveolar lavage (BAL) showed an increased number of S-100 positive cells. Steroid therapy resulted in complete resolution, and no S-100 positive cells were obtained in the follow-up BAL study.

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