Abstract
The effects of carbonic anhydrase inhibition on CO2 elimination in the lung were studied in terms of PCO2, PO2, PH, HCO3- and minute volume. The mongrel dogs were divided into four groups as shown in Table 1.
The following results were obtained.
A group: minute volume increased remarkably.
PaCO2 and arterial blood PH lowered.
B group: minute volume increased moderately.
PaCO2 raised, arterial blood PH and a-ADCO2 increased.
C group: minute volume was held constant (Hyperventilation).
PaCO2 raised and arterial blood PH lowered.
D group: minute volume was held constant (Hyperventilation).
PaCO2 raised remarkably and arterial blood PH lowered.
The suppression of CO2 elimination due to the administration of 50mg/kg of acetazolamide was clearly observed when bilateral renal blood vessels were ligated. This effects were more markedly seen when ventilation was artificially controlled. However, in intact dogs, the suppression of CO2 elimination was not observed.
The lowered CO2 elimination is presumed to be caused by inhibition of carbonic anhydrase present in the erythrocyte with acetazolamide administration.
