RES-O-MAT T_3 KIT AS AN IN VITRO THYROID FUNCTION TEST

Abstract

Res-O-Mat T_3 is used for an in vitro ^<131>I-T_3 diagnostic test to determining the T_3 binding capacity of serum. TBC index is obtained by comparing the quantity of T_3 bound by the patient's serum to that bound by pooled normal sera. Several basic experiments and clinical trials in 122 cases were performed. The results obtained are as follows : 1) Standard deviation of the results was 0.01,indicating reproducibility of this test to be satisfactory. 2) Decrease of TBC index was noted in the hyperthyroid cases with the increase of incubation time. 3) Increase of TBC index was noted in the hypothyroid cases with the increase of incubation time. 4) TBC index for the euthyroid cases was stable even when the incubation temperature was increased. 5) TBC index ranged from 0.87 to 1.06 (average 0.97) for 44 euthyroid, 0.55 to 0.97 (average 0.79) for 29 hyperthyroid, 1.12 to 1.25 (average 1.16) for 9 hypothyroid cases. 6) A good correlation between Res-O-Mat T_3 and ^<131>I-T_3 Resin sponge uptake test was observed.