Time-dependence Evaluation of the Primary Visual Cortex by ¹H MR-spectroscopy Using a Stimulation Control System

Abstract

Proton magnetic resonance spectroscopy (¹H MRS) is used to evaluate tumors and their remaining function under the assumption that event-related inspection and a method of data collection dependent on time are difficult. Therefore, this study examined the possibility that time depended on in MRS with a visual cortex. We conducted experiments using the following stimulations: REST: eyes are in a closed state, Control: eyes are in an open state, and Continuous: consecutive stimulation and time dependence in the visual cortex. We enabled dependence in time by collecting data with a system that controlled stimulation and experimented on stimulation for a short time using this system. The results showed that no significant difference in metabolites was seen in the REST, Control, and Consecutive stimulations. However, a significant difference was seen in Cr and NAA with time-dependent stimulation. Therefore, we considered functional magnetic resonance spectroscopy (fMRS) useful because time-dependent stimulation showed a meaningful difference with REST.