Primary angiosarcoma of the breast-a report of two cases-

Abstract

We report two cases of primary angiosarcoma of the breast, involving a 28–year–old woman with a tumor 7 cm in diameter in the right breast and a 44–year–old woman with a 2–cm mass in the left breast 14 months after mastectomy for a large angiosarcoma in the right breast. MRI scan showed repid and prolonged enhancement in the dynamic study in both cases. According to a review of 47 patients with the disease including ours reported between 1932 and 2007 in Japan, the mean age and mean tumor diameter were 39 years and 8.3 cm respectively. Mastectomy was performed for 42 patients (89.4%), while no axillary lymph node metastasis was reported. Thirty patients (63.8%) involved distant metastases in the mean follow–up time of 24.2 months, and 20 (42.6%) of then died. Kaplan–Meier analysis showed significantly better prognosis in patients with a tumor 2 cm or smaller in diameter than those larger than 2 cm.