Extramammary anal paget's disease associated with lung and gastric cancer

Abstract

A 76–year–old man had been aware of periproctal itching since he was 70years old. He had been using a commercial ointment for the itching.
He suffered from lung and gastric cancer at the age of 73 and 74, respectively. He underwent right superior lobectomy for the lung cancer and distal gastrectomy for the gastric cancer. Thereafter, itching and eczema became worse, and he was referred to our hospital. The biopsy of the periproctal eczema revealed that the lesion was Paget′s disease. According to the mapping biopsy, paget cell was detected at 1cm oral side from dentate line.
Abdominoperineal resection was performed. Extramammary anal Paget′s disease is often treated as intractable eczema. It is often associated with gastrointestinal cancer and other organ malignancy. The patient with intractable periproctal eczema should not be left out but further examination including the biopsy of the skin should be done.