Effect of prostaglandin e1 administration for hepatic blood flow maintenance after vascular clamping of hepatic hilum in hepatic resection

Abstract

In this study, the liver blood flow and effect of PGE1 administration were evaluated after vascular clamping of the hepatic hilum in a hepatic resection. We examined 27 hepatectomized cases (6 normal liver and 21 cirrhotic liver). These case were divided into 4 groups : PGE1 administered (n=3) and control (n=3) in normal liver, PGE1 administered (n=12) and control (n=9) in cirrhotic liver. Liver blood flow (ml/min/100 g) was compared at the following time points ; just before, during, and just after vascular clamping. In the normal liver, blood flow after declamping recovered immediately to the previous value in both the PGE1 administered and control groups with no significant difference. In the cirrhotic liver the blood flow after declamping did not recover to the previous value in the control, and was still significantly low ; meanwhile it returned to the previous value only in the PGE1 administered group.
In liver cirrhosis blood flow maintenance after vascular clamping was very difficult, and continuous injection of PGE1 seemed to be effective.