Abstract
A 46-year-old female patient noticed a tumor in her right breast since Feb. 2007 and came to our clinic in May 2007. An elastic hard, well circumscribed tumor of about 5 cm in diameter was palpable in the AC area of the right breast with a 2 cm diameter size lymphnode in the right axilla. Mammographic study confirmed the diagnosis of category 4. Ultrasonographic study revealed a relatively well circumscribed, non-homogeneous tumor over the right AC area. A diagnosis of cancer was made by a needle biopsy and a right modified radical mastectomy and axillary lymphnode dissection were performed. Pathological study of the resected specimen revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive synaptophysin and CD56, leading to the diagnosis of large cell neuroendocrine carcinoma (LCNEC). LCNEC is rare and definite treatment strategy has not been established and prognosis of the disease is not clear yet. We report the case here with some review of the literatures.
