A case of uterine metastasis from breast cancer detected by instrumental fdg-pet/ct

Abstract

We reported here a 55-year-old woman with uterine metastasis from breast cancer detected by instrumental FDG-PET/CT after mastectomy for right breast cancer (invasive lobular carcinoma, pT2, pN1, pM0, stageIIB, estrogen receptor (ER) (+), progesterone receptor (PgR) (+)). At the age of 53, she under went left axillary lymph node dissection for contra-lateral lymph node metastasis followed by endocrine-therapy of aromatase inhibitor. One and a half year after the surgery, a serum tumor marker (CEA) had gradually elevated. FDG-PET/CT revealed a pale increased uptake of radioisotope in the uterus and MRI demonstrated an enhanced diffuse enlarged uterus. Endometrial tissue specimens revealed suspicion of uterine metastasis of poorly-differentiated adenocarcinoma. Hysterectomy and adnexectomy were performed, and histopathological findings revealed diffusely infiltrative carcinoma, ER (+) and PgR (+), compatible with uterine metastasis from lobular carcinoma of right breast. Twenty-one months after the surgery, she has survived and is under treutmcnt with chemotherapy for skeletal and peritoneal relapses without major complaints.