Two cases of advanced gastric cancer treated with s-1/paclitaxel showing a complete responce on pathology

Abstract

Case 1 was a 67-year-old woman. She was diagnosed with type 2 advanced gastric cancer. Computed tomography (CT) revealed metastatic lymph nodes around the celiac artery [cT3 (SE), cN2, cM0, cH0, cP0 : c-stageIIIB]. Case 2 was a 66-year-old man. He was diagnosed with type 2 advanced gastric cancer on gastrointestinal endoscopy. CT and staging laparoscopy revealed metastatic lymph nodes in the lesser curvature and around the celiac artery [cT3 (SE), cN2, cM0, cH0, cP0 (CY0) : c-stageIIIB]. Both patients were treated with combination TS-1 and paclitaxel chemotherapy for 2 cycles. After chemotherapy, there was no change in case 1 ; case 2 showed a partial response. Both patients had a total gastrectomy and regional lymph node (D2) dissection. On pathology, no cancer cells were noted in the main tumor area or the lymph nodes ; the histological efficacy was evaluated as grade 3.