Two cases of intraductal papillary neoplasm of the bile duct

Abstract

There is a disease group characterized by intraductal papillary growth, mucin overproduction, gastric and intestinal epithelium formation, and expression of MUC2 and CK20. It is called intraductal papillary neoplasm of the bile duct (IPNB) and is acquiring increasing interest. Patient 1 was 65-year-old man who underwent expansion lobus sinister excision with a diagnosis of S4 cholangiocarcinoma. The definitive pathological diagnosis was intrahepatic cholangiocarcinoma with IPNB. Patient 2 was a 49-year-old woman who underwent liver 3 segmentectomy, extrahepatic bile duct excision and bile-duct anastomosis with a diagnosis of hilar cholangiocarcinoma. The definitive pathological diagnosis was IPNB, borderline. In the treatment of cholangiocarcinoma, a possibility of IPNB must be kept in mind.