Abstract
We experienced a family in which both the mother and daughter underwent surgery for ulcerative colitis (UC). The mother developed UC with the onset of melena at the age of 51, and was diagnosed with pancolitis. Although she was given steroids in addition to 5-ASA and followed, her symptoms waxed and waned. Despite increased steroid dose and granulocyte apheresis (GCAP), the symptoms exacerbated and the patient was admitted to our department on an emergency basis. Total colectomy, rectal mucosectomy, ileal pouch-anal anastomosis (IPAA), and ileostomy were immediately performed. The patient had an unremarkable course thereafter. The daughter developed UC with the onset of melena at the age of 18, and was given GCAP, steroids, immunomodulators, and other treatments for pancolitis and followed. However, the patient's symptoms waxed and waned and became a hindrance to her social life. The patient was diagnosed with refractory UC and underwent the same surgeries as her mother. Her postoperative course was favorable. Both mother and daughter underwent ileostomy closure and are currently being followed. No other members of this family had developed inflammatory bowel disease. The frequency of familial occurrence of UC has been reported as 1.8%. However, our literature search revealed no other cases of a mother-child pair undergoing IPAA.
