A case of chest wall fibrosarcoma as a second malignancy after radiation therapy for breast cancer

Abstract

We report a case of chest wall fibrosarcoma as a second malignancy after radiation therapy for breast cancer. The female patient had received radiation therapy to the chest wall and the regional lymph nodes after mastectomy at the age of 44 and had been suffered from severe radiation dermatitis. She noticed a subclavicular chest wall tumor 3cm in diameter at the age of 55. Although the tumor was resected with the diagnosis of local recurrence of breast cancer, the pathologic diagnosis was fibrosarcoma arising from the soft tissue. Two years later, an another chest wall tumor occurred. Chest wall resection and reconstruction with GORE-TEX^® sheet and a rectoabdominal myocutaneous flap was performed. Histologic findings were the same as the first tumor, fibrosarcoma. Multifocal tumor arising from the chest wall with severe radiation dermatitis convinced that the tumor was induced by the radiation therapy.