Abstract
A 63-year-old man, with anal canal carcinoma, responded to chemoradiation therapy given in combination with perioperative hyperthermia. The patient was admitted due to the presence of a tumor and pain in the anal canal region. Physical examination showed a 5.5×7 cm in diameter draining tumor located in the anal canal which extended into the buttocks. On histopathology, a well-differentiated adenocarcinoma of the anal canal was diagnosed. Post colostomy, chemoradiation therapy in combination with perioperative hyperthermia were given and resulted in significant demonstrated the tumor shrinkage. After the abdominoperineal rectal resection and lymph node dissection which included the inguinal lymph nodes, a femoral muscle flap, and epidermization were performed as part of reconstruction. Chemoradiotherapy for anal canal carcinoma is now widely used as adjuvant therapy. It is likely that combination treatment involving hyperthermia and chemoradiation can enhance tumor shrinkage. Cases with a large outgrowth of anal canal carcinoma require an extensive abdominoperineal resection. Tumor shrinkage prior to surgery appears to be very important for successful reconstruction. Our experience shows that hyperthermia, which has few adverse effects, is useful as an adjuvant therapy.
