Abstract
A 61-year-old man was admitted to our department for the treatment of a sigmoid colon tumor diagnosed by a colonoscopy performed on account of positive fecal occult blood test in April 2009. Histological examination of the endoscopic mucosal resection specimens revealed that the tumor was a mucosa associated lymphoid tissue (MALT) lymphoma. His stomach was positive for H. pylori infection. H. pylori eradication therapy was started in June and the eradication was proved successful in August. However, no remarkable regression of the tumor was recognized by colonoscopy in October. Then we started local radiotherapy for the MALT lymphoma in November 2009. Colonoscopic studies performed after January 2010 revealed regression of the MALT lymphoma. No exacerbation of the MALT lymphoma has occurred as of March 2011.
Although H. pylori eradication is the first choice therapy for MALT lymphoma of the stomach, no therapeutic guideline has been established as yet for MALT lymphomas of the large intestine. In this case, the eradication was ineffective and local radiotherapy was effective. There is still a possibility that local exacerbation or appearance of multiple intestinal lesions can occur, and thus we must carefully follow the patient's clinical course.
