Abstract
We report a 61-year-old Japanese male with a cholangiolocellular carcinoma. Abdominal enhanced computed tomography demonstrated an S7-liver tumor, about 45 mm in maximal diameter. CT examinations showed enhancement in the peripheral area in the early phase and prolonged enhancement in the delayed phase. The lesion was depicted as a hypoechoic nodule by ultrasonography. The tumor was seen as a hypointense nodule in the hepatobiliary phase of Gadoxetic acid disodium-enhanced liver magnetic resonance imaging. Upon confirmation of the diagnosis of intrahepatic cholangiolocellular carcinoma, S7 segmentectomy of the liver was performed. Microscopically, the tumor was composed of dense proliferation of small irregular tubules with fibrous stroma. Immunohistochemistry showed the carcinoma cells to be positive for EMA, NCAM, CK-7 and CK-19, EMA was strongly positive on the luminal surfaces of tubules. These findings are typical characteristics of cholangiolocellular carcinoma.
