Abstract
We analyzed factors that influence the operation outcome of early laparoscopic cholecystectomy (LC) for acute cholecystitis. We enrolled 61 patients with acute cholecystitis performed early LC within 96 hours from the onset of symptoms. Multivariate regression analysis was used to determine whether factors, including sex, age, time from the onset of symptoms, preoperative white blood cell count, preoperative C reactive protein, severity of cholecystitis, presence of cholecystolithiasis and past history of cholecystitis, had a significant association with the operation time, conversion rate to open cholecystectomy and postoperative complications. Operation time, conversion rate to open cholecystectomy, and postoperative complication rate was 124.1 minutes (average), 18.0%, and 13.1%, respectively. Male (p=0.0107), severity of moderate or severe (p=0.0371) and past history of cholecystitis (p=0.0009) were found to be significant risk factors for prolonged operation time of longer than 120 minutes. Acalculous cholecystitis (p=0.0345) was found to be associated with postoperative complications significantly.
Early LC for acute cholecystitis within 96 hours after the onset of symptoms should carefully be performed in the case of a male patient, severity of moderate or severe, acalculous cholecystitis and a patient with past history of cholecystitis.
