Abstract
The patient was a 45-year-old woman who had an endocrine carcinoma in the pancreatic body and tail with multiple hepatic metastases and a splenic venous tumor thrombus. First, transcatheter arterial chemo-embolization was performed for the hepatic metastases, and provided favorable locoregional control. Next, the patient underwent distal pancreatectomy along with removal the splenic venous thrombus. Microscopic findings showed extensive expression of trypsin, an acinar cell marker, followed by chromogranin A expression in 40-50% of the tumor cells and of synaptophysin in 20-30%. These are endocrine markers. According to the World Health Organization Classification, the tumor was diagnosed as mixed acinar-endocrine carcinoma. The patient remains alive, with no increase in hepatic metastases, 2 year after the operation.
