A case of g-csf producing esophageal squamous cell carcinoma

Abstract

The patient was a 76-year-old man who presented with dysphagia. Endoscopy revealed a protruding tumor in the thoracic esophagus. Laboratory data revealed leucocytosis and a high concentration of granulocyte-colony stimulating factor (G-CSF). The patient underwent an esophagectomy via a right thoracotomy and reconstruction by stomach tube. Histopathological examination revealed poorly-differntiated squamous cell carcinoma with positive expression for G-CSF by immunohistochemistry. The tumor was diagnosed as pT3, pN1, M0 and pStage III according to the TNM classification. The leucocytosis and the serum G-CSF level decreased to within normal limits after the operation. Adjuvant chemotherapy by Cisplatin and 5-fluorouracil was also performed. We herein report a case of G-CSF producing esophageal squamous cell carcinoma. To our knowledge, only ten cases have been reported in the Japanese literature.