Abstract
A 60-year-old woman with a history of appendectomy 10 years earlier was admitted due to right lower quadrant pain. Colonoscopic examination revealed a type 2 cecal tumor, analysis of a biopsy suggested signet ring cell carcinoma. Serum anti-p53 antibodies were elevated. At the laparotomy, multiple dissemination in the whole abdominal cavity was seen, so we performed an ileocecal resection. Histopathological examination revealed a goblet cell carcinoid of the appendix. After chemotheraphy, serum anti-p53 antibodies were decreased. Goblet cell carcinoid of the appendix is relatively rare with adenocarcinoma-like features and has a poor prognosis ; there have been 99 cases reported in Japan. Those cases with p53 immunostaining were 11 and 6 were positive, no reported cases measured serum anti-p53 antibodies were detected, we present this first case with a review of the literature.
