Abstract
A 61-year-old man admitted to our hospital because of anorexia showed marked leukocytosis (54,300/μl) on laboratory data. Gastrointestinal endoscopy showed type 1 gastric cancer in the upper gastric body, and biopsy revealed poorly differentiated adenocarcinoma. Preoperative laboratory data revealed a high serum level of granulocyte-colony stimulating factor (G-CSF) (229.0pg/ml). Because of persisting bleeding from gastric cancer, the patient underwent total gastrectomy plus distal pancreatectomy with splenectomy. Local recurrence, multiple liver metastases and multiple lung metastases were detected three months after the surgery. Despite chemotherapy, the patient died on the postoperative day 177. We present this case of G-CSF-producing gastric cancer which is relatively rare, together with a review of the Japanese literature.
