Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
Online ISSN : 1882-5133
Print ISSN : 1345-2843
ISSN-L : 1345-2843
Case Reports
A case of esophagaeal endocrine cell carcinoma with a remarkable response to neoadjuvant chemotherapy
Yukiyoshi MITAIsamu HOSHINOTakeshi TOYOZUMITsuguaki KOUNOYasunori AKUTSUHisahiro MATSUBARA
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2013 Volume 74 Issue 2 Pages 380-385

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Abstract
The patient was a 71-year-old man being treated for Vogt-Koyanagi-Harada disease. On whole body CT scan, thickening of the esophageal wall was identified. Endoscopic examinations revealed a type-2 tumor in the middle thoracic esophagus, which was diagnosed as an endocrine cell carcinoma on pathology. PET scans and contrast-enhanced CTs showed lymph node metastases in 3 fields, including No.101R, 106recR, 109R, and No.3. There were no distant metastases. The tumor was clinically diagnosed as T3 N2 M0 stage III. After two courses of neoadjuvant chemotherapy (NAC) using irinotecan and cisplatin, the patient showed a partial remission, and the tumor size was remarkably reduced. Subsequently, a subtotal esophagectomy was performed, and the histological effects of the NAC were reported as Grade 2. No viable tumor cells were observed in the 123 extracted lymph nodes. Post surgery the patient was given one course of adjuvant chemotherapy with irinotecan and cisplatin. Seven months after surgery, he is still alive and free of reccurence.
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© 2013 Japan Surgical Association
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